Therapeutics

Methods of Glycosylation and Bioconjugation
Background: The National Cancer Institute's Structural Glycobiology Laboratory is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, and/or commercialize methods of glycosylation and bioconjugation that can be (more...)
(Full Text)

Novel Cancer Immunotherapy Approaches For The Treatment And Prevention Of Cancer
Background: The National Cancer Institute's Laboratory of Tumor Immunology and Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize cancer immunotherapy using costimulation.  See (more...)
(Full Text)

Identification of T-Cell Receptors (TCR)
Background: The NIH National Cancer Institute's Surgery Branch seeks a research partner to further develop, evaluate, or commercialize adoptive immunotherapy therapeutics under a Collaboration Agreement or a Cooperative Research and Development Agreement (CRADA). Technology: Adoptive immunotherapy (more...)
(Full Text)

Treating Squamous Cell Cancer Using Beta-Catenin Splice Variants
Background: The National Cancer Institute, Division of Cancer Epidemiology and Genetics is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a method of treating cancer (more...)
(Full Text)

Novel Therapeutic For Inflammatory Disorders
Background: The National Cancer Institute's SAIC-Frederick Basic Sciences Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a novel inhibitor of the NF-kappa (more...)
(Full Text)

A New Series of Thalidomide Analogs with Potent Anti-Angiogenic and Anti-Cancer Properties
Background: The Medical Oncology Branch of the National Cancer Institute seeks a Cooperative Research and Development Agreement (CRADA) collaborator for preclinical and clinical development of thalidomide analogs. The classical orally active drug, thalidomide (N-alpha-phthalimidoglutarimide), a glutamic (more...)
(Full Text)

Selenocysteine Enables a New Platform for Immunoconjugates
The Experimental Transplantation and Immunology Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in forming a collaborative research alliance to further develop, evaluate, or commercialize (more...)
(Full Text)

TOPICAL AGENTS FOR THE PREVENTION AND TREATMENT OF SKIN TUMORS
Keywords: Therapeutics, Cancer, Dermatologic Diseases Background: The National Cancer Institute Laboratory of Cancer Biology and Genetics is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize topical agents (more...)
(Full Text)

HIV AND HCV THERAPEUTICS MADE FROM SCYTOVIRINS
Keywords: AIDS, HIV, Viral Diseases, Therapeutics   Background: The National Cancer Institute's Molecular Targets Development Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize novel HIV and (more...)
(Full Text)

Development of Novel Anti-Hiv Compounds
Background: The HIV DRP Retroviral Replication Laboratory at the National Cancer Institute-Frederick is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize active anti-viral compounds. The (more...)
(Full Text)

Recombinant Anti-mesothelin Immunotoxin SS1P (anti-mesothelin dsFv-PE38) as a Therapeutic Agent and Diagnostic Tool for Multiple Cancer Types
Background: The National Cancer Institute's Laboratory of Molecular Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop or commercialize the anti-mesothelin immunotoxin SS1P as an anti-tumor agent. (more...)
(Full Text)

Polypeptides For Stimulating Immune Responses
Background: The National Cancer Institute's Laboratory of Molecular Immunoregulation is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize HMGN polypeptides as immune enhancers or immune (more...)
(Full Text)

OLIGODEOXYNUCLEOTIDES AS ANTI-CANCER THERAPEUTICS AND DIAGNOSTICS
Keywords: Anti-Inflammatory Agents, Cancer, Therapeutics, Diagnostics   Background:The National Cancer Institute Laboratory of Experimental Immunology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize anti-cancer oligodeoxynucleotides.   Technology:NCI researchers have (more...)
(Full Text)

cDNA Fragments As Novel Anti-Cancer Therapeutics And Diagnostics
Background: The National Cancer Institute's Hatfield Clinical Research Center is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize cDNA fragments as antiangiogenic and antitumor therapy. Technology: This (more...)
(Full Text)

Fenoterol Analogues for Treating Congestive Heart Failure
Background: The Laboratory of Clinical Investigation of the National Institute of Aging is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize fenoterol analogues and their (more...)
(Full Text)

Biomarker to Predict Resistance to Doxorubicin Cancer Therapy
Background: The Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or (more...)
(Full Text)

Treatment of Cocaine Abuse and Other Mental Disorders
Background: The Medicinal Chemistry and Psychobiology Sections, National Institute on Drug Abuse-Intramural Research Program, National Institutes of Health, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, (more...)
(Full Text)

Method Of Treating Silicosis And Other Occupational Lung Diseases
Background: The National Cancer Institute's Laboratory of Experimental Immunology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize methods of treating silicosis and other occupational (more...)
(Full Text)

PCR Array For Detection Of Human Herpes Virus
Background: The National Cancer Institute's Advanced Technology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize virus-specific quantitative real-time RT-PCR arrays. Technology: This invention describes PCR-based (more...)
(Full Text)

Antisera to Detect Phosphorylated Phosphoinositide-Dependent Kinase 1 (PDK-
Background: The National Institutes of Health, National Center for Complementary and Alternative Medicine, Diabetes Unit is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize phospho-specific (more...)
(Full Text)

HIV-1 Nucleocapsid-p7 Protein-Nucleic Acid Antagonists as HIV Treatment
The National Cancer Institute (NCI)-Developmental Therapeutics Program (DTP) - Screening Technologies Branch (STB, in collaboration with the NCI-Retroviral Assembly and Protein Chemistry Laboratories and the AIDS Vaccine Program), have identified several classes of lead (more...)
(Full Text)

Angio-inhibitory Peptides Derived from Human TIMP-2
Background: The National Cancer Institute (NCI) is currently seeking cooperative partners to work with investigators in the Center for Cancer Research (CCR) to exploit, for drug development and clinical testing, novel TIMP-2 peptide-based inhibitors of (more...)
(Full Text)

Compounds That Reduce Cancer Multi-Drug Resistance
Background: The National Cancer Institute's Laboratory of Cell Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize compounds that demonstrate cytotoxicity against multi-drug resistant (more...)
(Full Text)

Griffithsin, a Novel anti-HIV Protein with Potential Microbicidal, Therapeutic and/or Purification Utilities
Background: The National Cancer Institute (NCI) Molecular Targets Development Program (MTDP) seeks a Cooperative Research and Development Agreement (CRADA) collaborator to develop griffithsin (GRFT), a novel, potent anti-HIV protein isolated from an aqueous extract of (more...)
(Full Text)

2nd -Generation, NO-Releasing Non-Steroidal Anti-Inflammatory Prodrugs
Background: The Laboratory of Comparative Carcinogenesis at the National Cancer Institute is seeking statements of capability, or interest, from parties interested in collaborative research to further develop, evaluate, and/or commercialize new and safer analgesic, anti-inflammatory, anti-thrombotic, (more...)
(Full Text)

Anakin Protein as a Prognostic Tool for Diagnosing Breast Cancer Outcome
Available for collaborative research toward commercial development and/or exclusive and non-exclusive licensing: Method of diagnosis for early metastasis and therapeutic inhibition of metastasis. Nucleic acid sequence of Anakin protein, an extracellular matrix (ECM) modifier gene. SiRNA sequences (more...)
(Full Text)

Methods To Treat Fatty Liver Disease
Background: The National Cancer Institute's Laboratory of Metabolism is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutics for fatty liver disease. Technology: Currently, there are (more...)
(Full Text)

Novel Therapeutics for the Treatment and Prevention of Avian Influenza
Background: The National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize cyanovirin-N for use against H5N1 influenza. The technology is also available (more...)
(Full Text)

Imaging Agents to Monitor the Distribution of Therapies Delivered to the Brain
Background: The National Institute of Neurological Disorders and Stroke (NINDS) seeks a commercial collaborator to work with NINDS in the development and commercialization of surrogate markers for monitoring the spatial distribution of therapeutic substances by (more...)
(Full Text)

Therapeutics Based On The Induced Internalization Of Surface Receptors
Background: The National Cancer Institute, Laboratory of Cellular Oncology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutics for diseases or conditions associated with (more...)
(Full Text)

Compounds For The Prevention And Treatment Of Skin Tumors
Background: The National Cancer Institute's Laboratory of Cellular Carcinogenesis and Tumor Promotion is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutics for treatment of (more...)
(Full Text)

Agents that Prevent Gene Silencing and Allow for Long Term Expression of Transgenes
Background: The National Cancer Institute's Laboratory of Molecular Pharmacology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize gamma-satellite DNA insulators for stable transgene expression. Technology: Introduction of (more...)
(Full Text)

Nitroxide Radical as a Treatment for Neurodegeneration
Background: The Human Iron Metabolism Section of the National Institute of Child Health and Human Development (NICHD) is seeking statements of capability or interest from parties interested in collaborative research to obtain pre-clinical data to (more...)
(Full Text)

Cancer Inhibitors Isolated from an African Plant
Background: The National Cancer Institute's Molecular Targets Development Program is seeking statements of interest from parties interested in collaborative research to further develop, evaluate, or commercialize cancer inhibitors isolated from the African plant Phyllanthus englerii. (more...)
(Full Text)

An Improved Non-Viral Gene Therapy System
Background: The National Cancer Institute's Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a tumor-specific gene therapy agent. The technology is also (more...)
(Full Text)

Novel Cancer Treatment Methods Using Angiogenesis Inhibitors
Background: The National Cancer Institute's Cell and Cancer Biology Branch, Laboratory of Extracellular Matrix Pathology is seeking statements of capability or interest from parties interested in collaborative research and/or partnership agreements to further develop and (more...)
(Full Text)

A New Technology for Identification of Hypoxia-Dependent Transcriptional Activation
Background: The Screening Technologies Branch of the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to obtain pre-clinical data to be used to further develop, evaluate, or (more...)
(Full Text)

Method To Treat Numerous Types Of Cancer Using Small Molecule Inhibitors
Background: The National Cancer Institute's Urologic Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize small molecule inhibitors of the c-Met signaling pathway. Technology: A (more...)
(Full Text)

Methods Of Preventing Tissue Ischemia
Background: The National Cancer Institute's Laboratory of Pathology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutics targeting vasodialation. Technology: Nitric oxide (NO) plays an (more...)
(Full Text)

Novel Agent to Promote Lung Development and Treat Lung Disease
Background: The National Cancer Institute's Laboratory of Metabolism is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a novel lung-enriched cytokine-like molecule as a clinical (more...)
(Full Text)

Nanoantibodies as Therapeutics and Diagnostics
Background: The National Cancer Institute Center for Cancer Research Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize nanoantibodies as therapeutics or diagnostics. The (more...)
(Full Text)

Human Monoclonal Antibody Against Mesothelin
Background: The National Cancer Institute's Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize human antibodies that act against mesothelin. NIH inventors have demonstrated (more...)
(Full Text)

Human and Improved Murine Monoclonal Antibodies Against CD22
Background: The National Cancer Institute's Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize human monoclonal antibodies expressed in types of lymphoma. CD22 is (more...)
(Full Text)

Anti-Cancer Agents that Inhibit Cell Motility, Angiogenesis, and Metastasis
Background: The National Cancer Institute's Urologic Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize anti-cancer drugs. Technology: The Grb2 protein, through its SH2 domain, mediates (more...)
(Full Text)

Anti-HIV Nucleoside Analogs
Background: The National Cancer Institute's HIV Drug Resistance Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize drugs with activity against HIV-1. Technology: This invention describes (more...)
(Full Text)

Therapeutics and Diagnostics for Non-Small Cell Lung Cancer (NSCLC)
Background: The National Cancer Institute's Center for Cancer Research, Laboratory of Human Carcinogenesis is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize unique genetic changes (more...)
(Full Text)

Uses of Cyanovirin-N for Anti-Hiv and Anti-Influenza Therapeutics and Prophylactics
Keywords: Therapeutics, Vaccines, HIV, Influenza, Cyanovirin-N (CV-N) Background: The National Cancer Institute's Molecular Targets Laboratory is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize cyanovirin-N HIV (more...)
(Full Text)

Method To Treat Numerous Dermatological Conditions
Background: The National Cancer Institute's Laboratory of Cell Biology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of DKK1 to treat abnormal (more...)
(Full Text)

Human Monoclonal Antibodies Against The Plague
Background: The National Cancer Institute's Protein Interactions Group is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutic human monoclonal antibodies directed against plague (Yersinia (more...)
(Full Text)

Method To Inactivate Viruses For Vaccine Development
Background: The National Cancer Institute's Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the use of hydrophobic crosslinkers for vaccine development using (more...)
(Full Text)

Fully Human NKG2D Monoclonal Antibody
Background: The National Cancer Institute's Experimental Transplantation and Immunology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize human monoclonal antibodies as therapeutic agents. Technology: NKG2D (more...)
(Full Text)

Sugar Substrates For Targeted-Drug Delivery
Background: The National Cancer Institute's Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the synthesis of UDP derivatives of C2 modified galactose (more...)
(Full Text)

Therapeutics To Treat Ocular Diseases
Background: The National Eye Institute's Section on Epithelial and Retinal Physiology and Disease (SERPD) is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize therapeutics (more...)
(Full Text)

Human Domain Antibody (dAb) Against HIV-1
Background: The National Cancer Institute's Center for Cancer Research Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize antibody-based therapeutics for HIV. Technology: The invention (more...)
(Full Text)

Biomarkers For Birt-Hogg-Dube (BHD) Syndrome And Renal Cancer
Background: The National Cancer Institute's Urologic Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize detection methods to screen a biomarker for (more...)
(Full Text)

Cancer Therapeutic Composed Of Cholera Exotoxin
The National Cancer Institute's Laboratory of Molecular Biology is seeking parties interested in collaborative research to further develop, evaluate, or commercialize immunotoxins composed of cholera exotoxin. R&D Status: In vitro proof-of-concept with results similar to (more...)
(Full Text)

DNA Repair Enzymes As Cancer Targets
Background: The National Cancer Institute's Laboratory of Molecular Pharmacology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize inhibitors of human tyrosyl-DNA phosphodiesterase (Tdp1) as (more...)
(Full Text)

Antibody-Based Cancer Biomarkers And Therapeutic Agents
Background: The National Cancer Institute's Mammary Biology and Tumorigenesis Laboratory is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize isoform-specifc antibodies to the human prolactin (more...)
(Full Text)

Cell Lines For Angiogenesis Screening
Background: The National Cancer Institute's Angiogenesis Core Facility is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize multicolored fluorescent cell lines and software for high-throughput (more...)
(Full Text)

HIV Vaccine Vectors
Background: The National Cancer Institute's Animal Models & Retroviral Vaccine Section is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize HTLV-II vectored HIV vaccines.  Technology: This invention (more...)
(Full Text)

Methods For Accurately Measuring And Regulating Adrenomedullin
Background: The National Cancer Institute's Angiogenesis Core Facility is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize methods to detect or regulate adrenomedullin (AM) levels. (more...)
(Full Text)

Methods To Facilitate The Clinical Manufacture Of Proteins Used In Cancer Immunotherapy Development
Background: The National Cancer Institute's Biological Research Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize methods to facilitate pharmaceutical purification and processing of (more...)
(Full Text)

Novel Method Of Preparing Vaccines
Background: The National Cancer Institute's Nanobiology Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize novel methods of preparing vaccines. A major direction in (more...)
(Full Text)

Gene Signature For Predicting Survival Outcome Of Human Hepatocellular Carcinoma (HCC)
Background: The National Cancer Institute Laboratory of Human Carcinogenesis is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize a gene signature for prognosis of (more...)
(Full Text)

Novel Dopamine Receptor Ligands As Therapeutics For Central Nervous System Disorders
Background: The National Institute on Drug Abuse's Medications Discovery Research Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize 4-phenylpiperazine derivatives as dopamine D3 (more...)
(Full Text)

Genetically-Modified T Cells As Cancer Immunotherapeutics
Background: The National Cancer Institute's Pediatric Oncology Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize genetically engineered lymphocytes with specificity for human survivin. A (more...)
(Full Text)

A Novel Target For Development Of Anti-Tumorigenic And Anti-Angiogenic Therapeutics And Diagnostics
Background: The National Cancer Institute's Angiogenesis Core Facility is seeking statements of capability or interest from parties interested in collaborative research to identify new biological functions for salcut-NH2 and to develop compounds that suppress (more...)
(Full Text)

Novel Methods To Detect Membrane Proteins
Background: The National Institute on Aging's Laboratory of Cardiovascular Sciences is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize modules to aid the study (more...)
(Full Text)

Anti-Tumor AGgents That Effect Premature Chromosome Condensation
Background: The National Cancer Institute Laboratory of Molecular Pharmacology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize lasonolide compounds as novel anti-cancer agents. Technology: Lasonolide A (more...)
(Full Text)

T Cell Receptors that Recognize the Tyrosinase Tumor Antigen
Keywords:  Adoptive Cell Transfer, Immunotherapy, T cell receptors (TCRs), tyrosinase tumor-associated antigen (TAA)   Background: The National Cancer Institute's Tumor Immunology Section is seeking statements of capability or interest from parties interested in collaborative research to (more...)
(Full Text)

Personalized Medicine Approach To Breast Cancer Diagnostics
Background: The National Cancer Institute's Genetics Branch is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize novel breast cancer therapeutics and diagnostics. Technology: Chromosome 8p11-12 is (more...)
(Full Text)

Cancer Therapeutic Based on T Cell Receptors Designed to Regiospecifically Release Interleukin-12
Keywords:  Immunotherapeutics, Cancer, T cell receptors (TCRs), Chimeric Antigen Receptors (CARs), human interleukin 12 (IL-12)     Background: The National Cancer Institute's Surgery Branch is seeking statements of capability or interest from parties interested in collaborative research to (more...)
(Full Text)

Novel Tumor-Associated Antigen for Cancer Diagnostics and Therapeutics
Keywords: Therapeutics, diagnostics, vaccines, cancer, melanoma, tumor-associated antigen, SPANX-B Background: The National Institute on Aging's Laboratory of Immunology is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or (more...)
(Full Text)

Therapeutics for Bowel Disorders
Keywords: Therapeutics, Gastrointestinal Diseases, Inflammatory Bowel Disorders, Crohn's Disease, Ulcerative Colitis (UC) Background:  The National Cancer Institute's Laboratory of Metabolism is seeking statements of capability or interest from parties interested in collaborative research to further develop, (more...)
(Full Text)